Jump to main content
Jump to site search


Ruthenium(II)-catalyzed olefination via carbonyl reductive cross-coupling

Author affiliations

Abstract

Natural availability of carbonyl groups offers reductive carbonyl coupling tremendous synthetic potential for efficient olefin synthesis, yet the catalytic carbonyl cross-coupling remains largely elusive. We report herein such a reaction, mediated by hydrazine under ruthenium(II) catalysis. This method enables facile and selective cross-couplings of two unsymmetrical carbonyl compounds in either an intermolecular or intramolecular fashion. Moreover, this chemistry accommodates a variety of substrates, proceeds under mild reaction conditions with good functional group tolerance, and generates stoichiometric benign byproducts. Importantly, the coexistence of KOtBu and bidentate phosphine dmpe is vital to this transformation.

Graphical abstract: Ruthenium(ii)-catalyzed olefination via carbonyl reductive cross-coupling

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Sep 2017, accepted on 08 Oct 2017 and first published on 09 Oct 2017


Article type: Edge Article
DOI: 10.1039/C7SC04207H
Citation: Chem. Sci., 2017, Advance Article
  • Open access: Creative Commons BY license
  •   Request permissions

    Ruthenium(II)-catalyzed olefination via carbonyl reductive cross-coupling

    W. Wei, X. Dai, H. Wang, C. Li, X. Yang and C. Li, Chem. Sci., 2017, Advance Article , DOI: 10.1039/C7SC04207H

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements