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Te-containing carbon dots for fluorescence imaging of superoxide anion in mice during acute strenuous exercise or emotional changes

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Abstract

Acute strenuous exercise and emotional changes are closely related to important aspects of human health. The superoxide anion (O2˙), as one of the primary reactive oxygen species (ROS), is intimately associated with major diseases. However, there is no relevant in vivo research for directly indicating the link between O2˙ level and acute physical exercise or emotional changes. Hence, we constructed three fluorescent probes for the detection of O2˙, including a Te-containing molecular probe and Se- and Te-containing CDs, and evaluated their properties such as selectivity, sensitivity, instantaneity and dynamic response to O2˙. Through performance comparisons, we found that the Te-containing CDs exhibited reversibility, instantaneity and the highest sensitivity (LOD ∼ 8.0 pM), under guarantees of specific recognition of O2˙, which ensure they are suitable for tracing native level changes in O2˙ within living systems. The probe was applied for monitoring the levels of O2˙ in mice under the state of intense exercise, irritability and mild depression, which led to the levels of O2˙ significantly increasing compared to the normal condition. Furthermore, we used the Te-containing CDs for real-time and dynamic imaging of O2˙ fluxes in the brain of mild depression mice and witnessed a positive correlation between O2˙ levels and depression. This work provides a new strategy for studying the relationship between acute exercise or emotional changes and diseases at the level of ROS.

Graphical abstract: Te-containing carbon dots for fluorescence imaging of superoxide anion in mice during acute strenuous exercise or emotional changes

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Publication details

The article was received on 05 Sep 2017, accepted on 06 Nov 2017 and first published on 08 Nov 2017


Article type: Edge Article
DOI: 10.1039/C7SC03878J
Citation: Chem. Sci., 2018, Advance Article
  • Open access: Creative Commons BY license
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    Te-containing carbon dots for fluorescence imaging of superoxide anion in mice during acute strenuous exercise or emotional changes

    W. Zhang, R. Wang, W. Liu, X. Wang, P. Li, W. Zhang, H. Wang and B. Tang, Chem. Sci., 2018, Advance Article , DOI: 10.1039/C7SC03878J

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