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Issue 12, 2017
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Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents

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Abstract

A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes as well as different alkynyl groups, presenting great potential for broad applications in synthesis, bioconjugation, and molecular imaging.

Graphical abstract: Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents

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Publication details

The article was received on 05 Aug 2017, accepted on 15 Oct 2017 and first published on 16 Oct 2017


Article type: Edge Article
DOI: 10.1039/C7SC03420B
Citation: Chem. Sci., 2017,8, 8265-8270
  • Open access: Creative Commons BY license
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    Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents

    K. Shen and Q. Wang, Chem. Sci., 2017, 8, 8265
    DOI: 10.1039/C7SC03420B

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