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Enantioselective Synthesis of Gem-diarylalkanes by Transition Metal-Catalyzed Asymmetric Arylations (TMCAAr)

Abstract

Chiral gem(1,1)-diaryl containing tertiary or quaternary stereogenic centers are present in many natural products and important pharmacophores. While numerous catalytic asymmetric methods enable access to 1,1-diaryl motifs, transition metal-catalyzed asymmetric arylations (TMCAAr) are among the most powerful method to prepare enantiopure gem-diarylalkane compounds. The main methodology includes enantioselective 1,2- or 1,4-additions across C=O, C=N and C=C bonds by arylmetallic reagents, aryl cross-couplings of olefins, benzylic (pseudo)halides and aziridines, asymmetric aryl substitution reactions of allylic substrates and isotopic benzylic C-H arylation.

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Publication details

The article was received on 04 Aug 2017, accepted on 07 Nov 2017 and first published on 08 Nov 2017


Article type: Minireview
DOI: 10.1039/C7SC03404K
Citation: Chem. Sci., 2017, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Enantioselective Synthesis of Gem-diarylalkanes by Transition Metal-Catalyzed Asymmetric Arylations (TMCAAr)

    T. Jia, P. Cao and J. Liao, Chem. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7SC03404K

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