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Issue 12, 2017
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Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging

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Abstract

Magnetic resonance imaging (MRI) using redox-active, EuII-containing complexes is one of the most promising techniques for noninvasively imaging hypoxia in vivo. In this technique, positive (T1-weighted) contrast enhancement persists in areas of relatively low oxidizing ability, such as hypoxic tissue. Herein, we describe a fluorinated, EuII-containing complex in which the redox-active metal is caged by intramolecular interactions. The position of the fluorine atoms enables temperature-responsive contrast enhancement in the reduced form of the contrast agent and detection of the oxidized contrast agent via MRI in vivo. Positive contrast is observed in 1H-MRI with Eu in the +2 oxidation state, and chemical exchange saturation transfer and 19F-MRI signal are observed with Eu in the +3 oxidation state. Contrast enhancement is controlled by the redox state of Eu, and modulated by the fluorous interactions that cage a bound water molecule reduce relaxivity in a temperature-dependent fashion. Together, these advancements constitute the first report of in vivo, redox-responsive imaging using 19F-MRI.

Graphical abstract: Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging

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Publication details

The article was received on 18 Jul 2017, accepted on 18 Oct 2017 and first published on 26 Oct 2017


Article type: Edge Article
DOI: 10.1039/C7SC03142D
Citation: Chem. Sci., 2017,8, 8345-8350
  • Open access: Creative Commons BY-NC license
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    Fluorinated EuII-based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging

    L. A. Basal, M. D. Bailey, J. Romero, Meser M. Ali, L. Kurenbekova, J. Yustein, R. G. Pautler and M. J. Allen, Chem. Sci., 2017, 8, 8345
    DOI: 10.1039/C7SC03142D

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