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Issue 10, 2017
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Room temperature C(sp2)–H oxidative chlorination via photoredox catalysis

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Abstract

Photoredox catalysis has been developed to achieve oxidative C–H chlorination of aromatic compounds using NaCl as the chlorine source and Na2S2O8 as the oxidant. The reactions occur at room temperature and exhibit exclusive selectivity for C(sp2)–H bonds over C(sp3)–H bonds. The method has been used for the chlorination of a diverse set of substrates, including the expedited synthesis of key intermediates to bioactive compounds and a drug.

Graphical abstract: Room temperature C(sp2)–H oxidative chlorination via photoredox catalysis

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Publication details

The article was received on 10 Jul 2017, accepted on 15 Aug 2017 and first published on 15 Aug 2017


Article type: Edge Article
DOI: 10.1039/C7SC03010J
Citation: Chem. Sci., 2017,8, 7009-7013
  • Open access: Creative Commons BY license
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    Room temperature C(sp2)–H oxidative chlorination via photoredox catalysis

    L. Zhang and X. Hu, Chem. Sci., 2017, 8, 7009
    DOI: 10.1039/C7SC03010J

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