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Issue 9, 2017
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Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums

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Abstract

NHC-catalyzed nucleophilic dearomatization of alkyl pyridiniums has been achieved to generate 1,4-dihydropyridines with high enantioselectivity. This is a rare example of catalytic, asymmetric addition of a nucleophile to the activated pyridinium that prefers C-4 functionalization leading to the 1,4-dihydropyridine with high selectivity.

Graphical abstract: Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums

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Publication details

The article was received on 13 Jun 2017, accepted on 24 Jul 2017 and first published on 03 Aug 2017


Article type: Edge Article
DOI: 10.1039/C7SC02648J
Citation: Chem. Sci., 2017,8, 6566-6569
  • Open access: Creative Commons BY license
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    Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums

    Darrin M. Flanigan and T. Rovis, Chem. Sci., 2017, 8, 6566
    DOI: 10.1039/C7SC02648J

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