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Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands

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Abstract

Chemically functionalized and nanostructured materials, which mimic the features of the natural extracellular matrix, provide a tool to organize cell surface receptors into nanoscale clusters and manipulate cell functions. However, the existing materials are mainly based on static structures. Herein, we developed a DNA based structure-switchable and multivalent material that acts as a ‘nano-spring’, enabling reversible control of membrane receptor function at the cell surface. This ‘nano-spring’ can be easily synthesized by rolling circle amplification and finely tuned by changing the circular template design. Using this ‘nano-spring’ to interact with cells, we have demonstrated that the movement of the DNA nanostructure is sufficient to direct a cell morphology change from the normal morphology to having numerous cell protrusions and affect the mRNA expression level of integrin related genes. This DNA nano-spring structure can be a competitive material for actively manipulating cell receptor function and may help us to understand the role of receptor mediated signalling cascades.

Graphical abstract: Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands

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Publication details

The article was received on 03 Jun 2017, accepted on 17 Aug 2017 and first published on 18 Aug 2017


Article type: Edge Article
DOI: 10.1039/C7SC02489D
Citation: Chem. Sci., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands

    K. Zhang, R. Deng, Y. Sun, L. Zhang and J. Li, Chem. Sci., 2017, Advance Article , DOI: 10.1039/C7SC02489D

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