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Issue 12, 2017
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De novo vesicle formation and growth: an integrative approach to artificial cells

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Abstract

The assembly of artificial cells provides a novel strategy to reconstruct life's functions and shed light on how life emerged on Earth and possibly elsewhere. A major challenge to the development of artificial cells is the establishment of simple methodologies to mimic native membrane generation. An ambitious strategy is the bottom-up approach, which aims to systematically control the assembly of highly ordered membrane architectures with defined functionality. This perspective will cover recent advances and the current state-of-the-art of minimal lipid architectures that can faithfully reconstruct the structure and function of living cells. Specifically, we will overview work related to the de novo formation and growth of biomimetic membranes. These studies give us a deeper understanding of the nature of living systems and bring new insights into the origin of cellular life.

Graphical abstract: De novo vesicle formation and growth: an integrative approach to artificial cells

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Publication details

The article was received on 24 May 2017, accepted on 13 Oct 2017 and first published on 26 Oct 2017


Article type: Perspective
DOI: 10.1039/C7SC02339A
Citation: Chem. Sci., 2017,8, 7912-7922
  • Open access: Creative Commons BY license
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    De novo vesicle formation and growth: an integrative approach to artificial cells

    A. Bhattacharya, R. J. Brea and N. K. Devaraj, Chem. Sci., 2017, 8, 7912
    DOI: 10.1039/C7SC02339A

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