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Issue 12, 2017
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Identification of catabolite control protein A from Staphylococcus aureus as a target of silver ions

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Abstract

Staphylococcus aureus is one of the most common pathogenic bacteria that causes human infectious diseases. The emergence of antibiotic-resistant strains of S. aureus promotes the development of new anti-bacterial strategies. Silver ions (Ag+) have attracted profound attention due to their broad-spectrum antimicrobial activities. Although the antibacterial properties of silver have been well known for many centuries, its mechanism of action remains unclear and its protein targets are rarely reported. Herein, we identify the catabolite control protein A (CcpA) of S. aureus as a putative target for Ag+. CcpA binds 2 molar equivalents of Ag+via its two cysteine residues (Cys216 and Cys242). Importantly, Ag+ binding induces CcpA oligomerization and abolishes its DNA binding capability, which further attenuates S. aureus growth and suppresses α-hemolysin toxicity. This study extends our understanding of the bactericidal effects of silver.

Graphical abstract: Identification of catabolite control protein A from Staphylococcus aureus as a target of silver ions

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Publication details

The article was received on 18 May 2017, accepted on 23 Sep 2017 and first published on 02 Oct 2017


Article type: Edge Article
DOI: 10.1039/C7SC02251D
Citation: Chem. Sci., 2017,8, 8061-8066
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    Identification of catabolite control protein A from Staphylococcus aureus as a target of silver ions

    X. Liao, F. Yang, R. Wang, X. He, H. Li, R. Y. T. Kao, W. Xia and H. Sun, Chem. Sci., 2017, 8, 8061
    DOI: 10.1039/C7SC02251D

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