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Synthesis and evaluation of MR probes for targeted-reporter imaging

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Abstract

Visualizing disease heterogeneity remains a challenging task since most imaging agents are targeted to a single receptor. We describe the development of an MR platform able to report on multiple molecular events. Enzyme activation and enhanced cellular uptake of this modular probe make it suitable for subsequent targeted-reporter imaging applications.

Graphical abstract: Synthesis and evaluation of MR probes for targeted-reporter imaging

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Publication details

The article was received on 16 May 2017, accepted on 10 Jun 2017 and first published on 13 Jun 2017


Article type: Edge Article
DOI: 10.1039/C7SC02217D
Citation: Chem. Sci., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Synthesis and evaluation of MR probes for targeted-reporter imaging

    K. D. Verma, J. O. Massing, S. G. Kamper, C. E. Carney, Keith W. MacRenaris, J. P. Basilion and T. J. Meade, Chem. Sci., 2017, Advance Article , DOI: 10.1039/C7SC02217D

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