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Issue 9, 2017
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Utilizing light-triggered plasmon-driven catalysis reactions as a template for molecular delivery and release

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Abstract

Due to the facile manipulation and non-invasive nature of light-triggered release, it is one of the most potent ways to selectively and remotely deliver a molecular target. Among the various carrier platforms, plasmonic nanoparticles possess advantages such as enhanced cellular uptake and easy loading of “cargo” molecules. Two general strategies are currently utilized to achieve light-induced molecule release from plasmonic nanoparticles. The first uses femtosecond laser pulses to directly break the bond between the nanoparticle and the loaded target. The other requires significant photo-thermal effects to weaken the interaction between the cargo molecules and nanoparticle-attached host molecules. Different from above mechanisms, herein, we introduce a new light-controlled molecular-release method by taking advantage of a plasmon-driven catalytic reaction at the particle surface. In this strategy, we link the target to a plasmon responsive molecule, 4-aminobenzenethiol (4-ABT), through the robust and simple EDC coupling reaction and subsequently load the complex onto the particles via the strong Au–thiol interaction. Upon continuous-wave (CW) laser illumination, the excited surface plasmon catalyzes the formation of 4,4′-dimercaptoazobenzenethiol (DMAB) and simultaneously releases the loaded molecules with high efficiency. This method does not require the use of high-power pulsed lasers, nor does it rely on photo-thermal effects. We believe that plasmon-driven release strategies open a new direction for the designing of next-generation light-triggered release processes.

Graphical abstract: Utilizing light-triggered plasmon-driven catalysis reactions as a template for molecular delivery and release

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Publication details

The article was received on 10 May 2017, accepted on 27 Jun 2017 and first published on 28 Jun 2017


Article type: Edge Article
DOI: 10.1039/C7SC02089A
Citation: Chem. Sci., 2017,8, 5902-5908
  • Open access: Creative Commons BY-NC license
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    Utilizing light-triggered plasmon-driven catalysis reactions as a template for molecular delivery and release

    X. Gu, H. Wang and J. P. Camden, Chem. Sci., 2017, 8, 5902
    DOI: 10.1039/C7SC02089A

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