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Issue 9, 2017
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Light-responsive paper strips as CO-releasing material with a colourimetric response

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Abstract

Carbon monoxide (CO) is known for its multifaceted role in human physiology, and molecules that release CO in a controlled way have been proposed as therapeutic drugs. In this work, a light-responsive CO-releasing molecule (CORM-Dabsyl) showed a strong colourimetric response upon photochemical CO-release, owing to the tight conjugation of a Mn(I) tricarbonyl centre to a dabsyl chromophoric ligand (L). Whereas the complex was very stable in the dark in nitrogen-purged aqueous media, CO-release was effectively triggered using 405 nm irradiation. CORM-Dabsyl, L and the inactive product iCORM-Dabsyl have been investigated by DFT and TD-DFT calculations. Only mild toxicity of CORM-Dabsyl was observed against LX-2 and HepaRG® human cell lines (IC50 ∼ 30 μM). Finally, to develop a CO storage and release material that is readily applicable to therapeutic situations, CORM-Dabsyl was loaded on low-cost and easily disposable paper strips, from which the light triggered CO-release was conveniently visible with the naked eye.

Graphical abstract: Light-responsive paper strips as CO-releasing material with a colourimetric response

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Publication details

The article was received on 16 Apr 2017, accepted on 25 Jul 2017 and first published on 26 Jul 2017


Article type: Edge Article
DOI: 10.1039/C7SC01692A
Citation: Chem. Sci., 2017,8, 6555-6560
  • Open access: Creative Commons BY license
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    Light-responsive paper strips as CO-releasing material with a colourimetric response

    U. Reddy G., J. Liu, P. Hoffmann, J. Steinmetzer, H. Görls, S. Kupfer, S. H. C. Askes, U. Neugebauer, S. Gräfe and A. Schiller, Chem. Sci., 2017, 8, 6555
    DOI: 10.1039/C7SC01692A

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