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Issue 8, 2017
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Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes

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Abstract

The characterization of protein-nanoparticle assemblies in solution remains a challenge. We demonstrate a technique based on a graphene microelectrode for structural-functional analysis of model systems composed of nanoparticles enclosed in open-pore and closed-pore ferritin molecules. The method readily resolves the difference in accessibility of the enclosed nanoparticle for charge transfer and offers the prospect for quantitative analysis of pore-mediated transport, while shedding light on the spatial orientation of the protein subunits on the nanoparticle surface, faster and with higher sensitivity than conventional catalysis methods.

Graphical abstract: Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes

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Publication details

The article was received on 07 Apr 2017, accepted on 12 Jun 2017 and first published on 13 Jun 2017


Article type: Edge Article
DOI: 10.1039/C7SC01565H
Citation: Chem. Sci., 2017,8, 5329-5334
  • Open access: Creative Commons BY license
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    Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes

    J. Ping, Katherine W. Pulsipher, R. Vishnubhotla, J. A. Villegas, T. L. Hicks, S. Honig, J. G. Saven, I. J. Dmochowski and A. T. C. Johnson, Chem. Sci., 2017, 8, 5329
    DOI: 10.1039/C7SC01565H

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