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Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method

Abstract

Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallographically determine the absolute configuration of organic compounds bearing chiral quaternary carbons (including tetra-substituted ones) that are synthesized by recently developed enantioselective catalytic reactions.

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Publication details

The article was received on 06 Apr 2017, accepted on 08 May 2017 and first published on 16 May 2017


Article type: Edge Article
DOI: 10.1039/C7SC01524K
Citation: Chem. Sci., 2017, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method

    S. Sairenji, T. Kikuchi, M. A. Abozeid, S. Takizawa, H. Sasai, Y. Ando, K. Ohmatsu, T. Ooi and M. Fujita, Chem. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7SC01524K

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