Jump to main content
Jump to site search

Issue 7, 2017
Previous Article Next Article

Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi

Author affiliations

Abstract

Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in Monascus ruber M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and in vitro chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provides a roadmap for future pathway engineering efforts directed towards the selective production of the most valuable pigments and serves as a model for the biosynthesis of fungal azaphilones in general.

Graphical abstract: Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jan 2017, accepted on 20 Apr 2017 and first published on 24 Apr 2017


Article type: Edge Article
DOI: 10.1039/C7SC00475C
Citation: Chem. Sci., 2017,8, 4917-4925
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi

    W. Chen, R. Chen, Q. Liu, Y. He, K. He, X. Ding, L. Kang, X. Guo, N. Xie, Y. Zhou, Y. Lu, R. J. Cox, I. Molnár, M. Li, Y. Shao and F. Chen, Chem. Sci., 2017, 8, 4917
    DOI: 10.1039/C7SC00475C

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements