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Issue 6, 2017
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Integration of G-quadruplex and DNA-templated Ag NCs for nonarithmetic information processing

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Abstract

To create sophisticated molecular logic circuits from scratch, you may not believe how common the building blocks can be and how diverse and powerful such circuits can be when scaled up. Using the two simple building blocks of G-quadruplex and silver nanoclusters (Ag NCs), we experimentally construct a series of multifunctional, label-free, and multi-output logic circuits to perform nonarithmetic functions: a 1-to-2 decoder, a 4-to-2 encoder, an 8-to-3 encoder, dual transfer gates, a 2 : 1 multiplexer, and a 1 : 2 demultiplexer. Moreover, a parity checker which is capable of identifying odd and even numbers from natural numbers is constructed conceptually. Finally, a multi-valued logic gate (ternary inhibit gate) is readily achieved by taking this DNA/Ag NC system as a universal platform. All of the above logic circuits share the same building blocks, indicating the great prospects of the assembly of nanomaterials and DNA for biochemical logic devices. Considering its biocompatibility, the novel prototypes developed here may have potential applications in the fields of biological computers and medical diagnosis and serve as a promising proof of principle in the not-too-distant future.

Graphical abstract: Integration of G-quadruplex and DNA-templated Ag NCs for nonarithmetic information processing

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Publication details

The article was received on 24 Jan 2017, accepted on 05 Apr 2017 and first published on 06 Apr 2017


Article type: Edge Article
DOI: 10.1039/C7SC00361G
Citation: Chem. Sci., 2017,8, 4211-4222
  • Open access: Creative Commons BY-NC license
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    Integration of G-quadruplex and DNA-templated Ag NCs for nonarithmetic information processing

    R. Gao, T. Yao, X. Lv, Y. Zhu, Y. Zhang and S. Shi, Chem. Sci., 2017, 8, 4211
    DOI: 10.1039/C7SC00361G

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