Integration of G-quadruplex and DNA-templated Ag NCs for Nonarithmetic Information Processing
To implement sophisticated molecular logic circuits from scratch, you may not believe how common the building blocks can be and how diverse, powerful such circuits can be scaled up. Using the two simple building blocks: G-quadruplex and silver nanoclusters (Ag NCs), we experimentally construct a series of multifunctional label-free, multi-output logic circuits to perform nonarithmetic functions: 1-to-2 decoder, 4-to-2 encoder, 8-to-3 encoder, dual transfer gates, 2:1 multiplexer and 1:2 demultiplexer. Moreover, a parity checker which is capable of identification of odd and even numbers from natural numbers is constructed conceptually. Finally, a multi-valued logic gate (ternary Inhibit gate) is readily achieved by taking this DNA/Ag NCs system as a universal platform. All the above logic circuits share the same building blocks, indicating the great prospects of the assembly of nanomaterials and DNA for biochemical logic devices. Considering its biocompatibility, the novel prototypes developed here may have potential applications in the field of biological computer and medical diagnosis and serve as a promising proof of principle in the not-too-distant future.