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Issue 4, 2017
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Stepwise crystallographic visualization of dynamic guest binding in a nanoporous framework

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Abstract

Binding sites are at the heart of all host–guest systems, whether biological or chemical. When considering binding sites that form covalent bonds with the guest, we generally envision a single, highly specific binding motif. Through single-crystal X-ray crystallography, the dynamic binding of a guest that displays a variety of covalent binding motifs in a single site of adsorption is directly observed for the first time. The stepwise crystallographic visualization of the incorporation of I2 within a porous MOF is presented, wherein the preferred binding motifs throughout the uptake process are identified. The guest I2 molecules initially bind with terminal iodide atoms of the framework to form [I4]2− units. However, as the adsorption progresses, the I2 molecules are observed to form less energetically favorable I3 groups with the same framework iodide atoms, thereby allowing for more guest molecules to be chemisorbed. At near saturation, even more binding motifs are observed in the same pores, including both physisorbed and chemisorbed guest molecules. Herein, we present the successful identification of a unique set of host–guest interactions which will drive the improvement of high capacity iodine capture materials.

Graphical abstract: Stepwise crystallographic visualization of dynamic guest binding in a nanoporous framework

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Publication details

The article was received on 18 Jan 2017, accepted on 11 Feb 2017 and first published on 13 Feb 2017


Article type: Edge Article
DOI: 10.1039/C7SC00267J
Citation: Chem. Sci., 2017,8, 3171-3177
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    Stepwise crystallographic visualization of dynamic guest binding in a nanoporous framework

    G. Brunet, D. A. Safin, M. Z. Aghaji, K. Robeyns, I. Korobkov, T. K. Woo and M. Murugesu, Chem. Sci., 2017, 8, 3171
    DOI: 10.1039/C7SC00267J

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