Issue 5, 2017

Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

Abstract

Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY ≈ 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible NIR-II probes: SXH, SDH, and H1 NPs were constructed via different chemical strategies based on H1, and then their potential to be used in in vivo tumor imaging and image-guided surgery in the NIR-II region was explored. High levels of uptake were obtained for both passive and active tumor targeting probes SXH and SDH. Furthermore, high resolution imaging of blood vessels on tumors and the whole body of living mice using H1 NPs for the first time has demonstrated precise NIR-II image-guided sentinel lymph node (SLN) surgery.

Graphical abstract: Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

Supplementary files

Article information

Article type
Edge Article
Submitted
18 Jan 2017
Accepted
18 Feb 2017
First published
21 Feb 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 3489-3493

Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

Y. Sun, M. Ding, X. Zeng, Y. Xiao, H. Wu, H. Zhou, B. Ding, C. Qu, W. Hou, A. Er-bu, Y. Zhang, Z. Cheng and X. Hong, Chem. Sci., 2017, 8, 3489 DOI: 10.1039/C7SC00251C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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