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Issue 4, 2017
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Synthesis and stabilities of peptide-based [1]rotaxanes: molecular grafting onto lasso peptide scaffolds

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Abstract

The chemical synthesis of peptide-based [1]rotaxanes (lasso peptides) was achieved by [2]rotaxane formation followed by two chemoselective ligation reactions. Our approach enabled incorporation of various peptide sequences into a common rotaxane structure. The synthetic lasso peptides were characterized by NMR, chromatography, and partial degradation by proteases. A linear peptide epitope grafted onto the rotaxane scaffold showed significantly improved proteolytic stability.

Graphical abstract: Synthesis and stabilities of peptide-based [1]rotaxanes: molecular grafting onto lasso peptide scaffolds

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Publication details

The article was received on 03 Jan 2017, accepted on 25 Jan 2017 and first published on 26 Jan 2017


Article type: Edge Article
DOI: 10.1039/C7SC00021A
Citation: Chem. Sci., 2017,8, 2878-2884
  • Open access: Creative Commons BY-NC license
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    Synthesis and stabilities of peptide-based [1]rotaxanes: molecular grafting onto lasso peptide scaffolds

    F. Saito and J. W. Bode, Chem. Sci., 2017, 8, 2878
    DOI: 10.1039/C7SC00021A

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