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Copper-catalyzed direct alkylation of heteroarenes

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Abstract

An efficient and broadly applicable process is reported for the direct alkylation of C–H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

Graphical abstract: Copper-catalyzed direct alkylation of heteroarenes

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Publication details

The article was received on 22 Dec 2016, accepted on 17 Mar 2017 and first published on 20 Mar 2017


Article type: Edge Article
DOI: 10.1039/C6SC05622A
Citation: Chem. Sci., 2017, Advance Article
  • Open access: Creative Commons BY-NC license
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    Copper-catalyzed direct alkylation of heteroarenes

    C. Theunissen, J. Wang and G. Evano, Chem. Sci., 2017, Advance Article , DOI: 10.1039/C6SC05622A

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