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Issue 5, 2017
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Copper-catalyzed direct alkylation of heteroarenes

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An efficient and broadly applicable process is reported for the direct alkylation of C–H bonds in heteroarenes, privileged scaffolds in many areas of science. This reaction is based on the copper-catalyzed addition of alkyl radicals generated from activated secondary and tertiary alkyl bromides to a wide range of arenes, including furans, thiophenes, pyrroles, and their benzo-fused derivatives, as well as coumarins and quinolinones.

Graphical abstract: Copper-catalyzed direct alkylation of heteroarenes

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The article was received on 22 Dec 2016, accepted on 17 Mar 2017 and first published on 20 Mar 2017

Article type: Edge Article
DOI: 10.1039/C6SC05622A
Citation: Chem. Sci., 2017,8, 3465-3470
  • Open access: Creative Commons BY-NC license
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    Copper-catalyzed direct alkylation of heteroarenes

    C. Theunissen, J. Wang and G. Evano, Chem. Sci., 2017, 8, 3465
    DOI: 10.1039/C6SC05622A

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