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Issue 4, 2017
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Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

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Abstract

We developed novel zwitterionic near infrared (NIR) fluorescent agents (ABZWCY-HPβCD and AAZWCY-HPβCD), which exhibit favorable hydrophilicity, low plasma protein binding, high stability and non-toxicity. These attractive characteristics ensure that they are excreted rapidly, without any skin accumulation or metabolism in vivo. More importantly, zwitterionic HPβCD based agents can be efficiently filtrated by the glomerulus and completely excreted through the kidneys into urine without reabsorption or secretion in the kidney proximal tubule. Relying on these novel zwitterionic NIR agents and a transcutaneous device, we demonstrate a rapid, robust and biocompatible approach for assessing kidney function in rat models of both healthy rats and those with kidney disease, without the need for time-consuming blood/urine sample preparation. Our work provides a promising tool for in vivo real-time non-invasive kidney function assessment in preclinical applications.

Graphical abstract: Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

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Publication details

The article was received on 16 Nov 2016, accepted on 08 Jan 2017 and first published on 11 Jan 2017


Article type: Edge Article
DOI: 10.1039/C6SC05059J
Citation: Chem. Sci., 2017,8, 2652-2660
  • Open access: Creative Commons BY license
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    Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

    J. Huang, S. Weinfurter, C. Daniele, R. Perciaccante, R. Federica, L. Della Ciana, J. Pill and N. Gretz, Chem. Sci., 2017, 8, 2652
    DOI: 10.1039/C6SC05059J

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