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Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth

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Abstract

Nitric oxide (NO), an endogenously produced free radical species, is an extremely important signalling molecule in several biochemical processes related to neurotransmission, neuronal communication, and vasodilation, to name a few. Other than relying on endogenous synthesis, intracellular NO delivery presents an interesting challenge to fully exploit the therapeutic potential of this gaseous molecule. We have applied a self-assembling peptide conjugate strategy to devise a construct carrying a NO-release arm, which can be activated under standard redox conditions. Consequently, a tryptophan-based peptide carrier was designed, which self-assembled in the solution phase to afford soft nanospherical structures, and released NO in Neuro2a cell line, resulting in neurite outgrowth.

Graphical abstract: Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth

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Publication details

The article was received on 14 Nov 2016, accepted on 19 Jun 2017 and first published on 20 Jun 2017


Article type: Edge Article
DOI: 10.1039/C6SC05017D
Citation: Chem. Sci., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Self-assembling soft structures for intracellular NO release and promotion of neurite outgrowth

    H. A. Pal, S. Mohapatra, V. Gupta, S. Ghosh and S. Verma, Chem. Sci., 2017, Advance Article , DOI: 10.1039/C6SC05017D

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