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Edge Article

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy

Corresponding authors
Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, USA
E-mail: peter.tonge@stonybrook.edu
C4 Therapeutics, Cambridge, USA
E-mail: stewfisher@slfisherconsulting.com
Chem. Sci., 2017, Advance Article

DOI: 10.1039/C6SC03306G
Received 26 Jul 2016, Accepted 10 Mar 2017
First published online 14 Mar 2017
Open Access
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