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Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

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Abstract

Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with nBuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, nBuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at −65 °C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation.

Graphical abstract: Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

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Publication details

The article was received on 20 Oct 2017, accepted on 09 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7RE00176B
Citation: React. Chem. Eng., 2017, Advance Article
  • Open access: Creative Commons BY license
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    Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

    B. Gutmann, M. Köckinger, G. Glotz, T. Ciaglia, E. Slama, M. Zadravec, S. Pfanner, M. C. Maier, H. Gruber-Wölfler and C. Oliver Kappe, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00176B

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