Issue 6, 2017

Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

Abstract

Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with nBuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, nBuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at −65 °C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation.

Graphical abstract: Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

Supplementary files

Article information

Article type
Paper
Submitted
20 Oct 2017
Accepted
09 Nov 2017
First published
09 Nov 2017
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2017,2, 919-927

Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroform

B. Gutmann, M. Köckinger, G. Glotz, T. Ciaglia, E. Slama, M. Zadravec, S. Pfanner, M. C. Maier, H. Gruber-Wölfler and C. Oliver Kappe, React. Chem. Eng., 2017, 2, 919 DOI: 10.1039/C7RE00176B

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