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Green synthesis of α-amino acids by electrochemical carboxylation of imines in a flow microreactor

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Abstract

A new approach for the green synthesis of α-amino acids using electrochemical carboxylation of imines in a flow microreactor is described. This method has the major advantage of not requiring sensitive, expensive, or toxic reagents. In addition, the reaction could be conducted using single flow-through operations, without the need for sacrificial anodes and under very mild and green conditions. Our microreactor system enabled the electrochemical synthesis of N-phenylphenylglycine derivatives in good to moderate yields.

Graphical abstract: Green synthesis of α-amino acids by electrochemical carboxylation of imines in a flow microreactor

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Publication details

The article was received on 12 Sep 2017, accepted on 07 Nov 2017 and first published on 07 Nov 2017


Article type: Paper
DOI: 10.1039/C7RE00149E
Citation: React. Chem. Eng., 2017, Advance Article
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    Green synthesis of α-amino acids by electrochemical carboxylation of imines in a flow microreactor

    Y. Qu, C. Tsuneishi, H. Tateno, Y. Matsumura and M. Atobe, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00149E

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