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Issue 5, 2017
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Microfluidic synthesis of α-ketoesters via oxidative coupling of acetophenones with alcohols under metal-free conditions

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Abstract

An efficient and novel method for the synthesis of α-ketoesters has been developed via oxidative coupling of acetophenones with alcohols under TBHP/I2/DBU conditions in a microfluidic chip reactor, which has a wide substrate scope, uses a lower dosage of iodine and affords higher product yields in only a few seconds. Moreover, a scale-up continuous flow system is also feasible and the plausible reaction mechanism has been proposed based on a series of control experiments.

Graphical abstract: Microfluidic synthesis of α-ketoesters via oxidative coupling of acetophenones with alcohols under metal-free conditions

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Publication details

The article was received on 22 Jul 2017, accepted on 10 Aug 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7RE00107J
Citation: React. Chem. Eng., 2017,2, 650-655
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    Microfluidic synthesis of α-ketoesters via oxidative coupling of acetophenones with alcohols under metal-free conditions

    S. Guo, Z. Dai, J. Hua, Z. Yang, Z. Fang and K. Guo, React. Chem. Eng., 2017, 2, 650
    DOI: 10.1039/C7RE00107J

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