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Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

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Abstract

A novel approach to synthesize hydroxy lactones using flow chemistry is reported. The system could be applied to a variety of functionalized alkenoic acids allowing the simple and eco-friendly generation of lactonic products within one hour (50 min). The reaction was optimized in terms of efficiency, productivity, resources and eco-sustainability using an integrated flow process assisted by in-line work-up and purification. In one example, the method was scaled to deliver 22 mmol of the product.

Graphical abstract: Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

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Publication details

The article was received on 12 Jun 2017, accepted on 06 Jul 2017 and first published on 06 Jul 2017


Article type: Communication
DOI: 10.1039/C7RE00083A
Citation: React. Chem. Eng., 2017, Advance Article
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    Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

    B. Cerra, F. Mangiavacchi, C. Santi, A. M. Lozza and A. Gioiello, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00083A

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