Issue 4, 2017

Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

Abstract

A novel approach to synthesize hydroxy lactones using flow chemistry is reported. The system could be applied to a variety of functionalized alkenoic acids allowing the simple and eco-friendly generation of lactonic products within one hour (50 min). The reaction was optimized in terms of efficiency, productivity, resources and eco-sustainability using an integrated flow process assisted by in-line work-up and purification. In one example, the method was scaled to deliver 22 mmol of the product.

Graphical abstract: Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

Supplementary files

Article information

Article type
Communication
Submitted
12 Jun 2017
Accepted
06 Jul 2017
First published
06 Jul 2017

React. Chem. Eng., 2017,2, 467-471

Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

B. Cerra, F. Mangiavacchi, C. Santi, A. M. Lozza and A. Gioiello, React. Chem. Eng., 2017, 2, 467 DOI: 10.1039/C7RE00083A

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