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A direct strategy to hybrid benzothiazole-carbamate moieties via O-acylation of phenols under metal-organic framework catalysis

Abstract

Carbamates containing benzothiazole moiety was synthesized via cross-dehydrogenative coupling of phenols with N,N-disubstituted formamides utilizing metal-organic framework Cu-CPO-27 as a productive and recyclable heterogeneous catalyst. These hybrid structures would combine the benefits from both carbamates and benzothiazoles in terms of biological and pharmaceutical activities. The Cu-CPO-27 framework expressed better catalytic efficiency for the synthesis of carbamates than various MOFs. It was feasible to recover and reuse the catalyst without a appreciable deterioration in catalytic efficiency. To our best knowledge, this is the first heterogeneous catalytic protocol towards the generation of a hybrid carbamate-benzothiazole skeleton via direct coupling reaction.

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Publication details

The article was received on 17 May 2017, accepted on 13 Jul 2017 and first published on 13 Jul 2017


Article type: Paper
DOI: 10.1039/C7RE00067G
Citation: React. Chem. Eng., 2017, Accepted Manuscript
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    A direct strategy to hybrid benzothiazole-carbamate moieties via O-acylation of phenols under metal-organic framework catalysis

    N. T. S. Phan, C. K. Nguyen, N. B. Nguyen, O. N. Chu, T. T. Nguyen and H. Dang, React. Chem. Eng., 2017, Accepted Manuscript , DOI: 10.1039/C7RE00067G

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