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A direct strategy to synthesize hybrid benzothiazole–carbamate moieties via O-acylation of phenols under metal–organic framework catalysis

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Abstract

Carbamates containing a benzothiazole moiety were synthesized via cross-dehydrogenative coupling of phenols with N,N-disubstituted formamides utilizing the metal–organic framework Cu-CPO-27 as a productive and recyclable heterogeneous catalyst. These hybrid structures would combine the benefits from both carbamates and benzothiazoles in terms of biological and pharmaceutical activities. The Cu-CPO-27 framework exhibited better catalytic efficiency for the synthesis of carbamates than various MOFs. It was feasible to recover and reuse the catalyst without an appreciable deterioration in catalytic efficiency. To the best of our knowledge, this is the first heterogeneous catalytic protocol towards the generation of a hybrid carbamate–benzothiazole skeleton via direct coupling reaction.

Graphical abstract: A direct strategy to synthesize hybrid benzothiazole–carbamate moieties via O-acylation of phenols under metal–organic framework catalysis

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Publication details

The article was received on 17 May 2017, accepted on 13 Jul 2017 and first published on 13 Jul 2017


Article type: Paper
DOI: 10.1039/C7RE00067G
Citation: React. Chem. Eng., 2017, Advance Article
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    A direct strategy to synthesize hybrid benzothiazole–carbamate moieties via O-acylation of phenols under metal–organic framework catalysis

    C. K. Nguyen, N. B. Nguyen, O. N. Chu, H. V. Dang, T. T. Nguyen and N. T. S. Phan, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00067G

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