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Selective functionalization of complex heterocycles via an automated strong base screening platform

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Abstract

Knochel–Hauser bases, derived from 2,2,6,6-tetramethylpiperidinyl (TMP) metal amides, offer exceptional selectivity and functional group tolerance in the regioselective metalation of arenes and heteroarenes. The selectivity, stability and yield of these reactions are highly dependent on the nature of the base, additive and deprotonation temperature. We have developed and validated an automated micro-scale high throughput experimentation (HTE) approach to rapidly optimize base and temperature matrices. We describe the application of this approach to the regioselective functionalization of a variety of complex heterocycles and extension to the preparation of organometallic reagents for transition metal catalyzed cross-coupling screens.

Graphical abstract: Selective functionalization of complex heterocycles via an automated strong base screening platform

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Publication details

The article was received on 05 May 2017, accepted on 16 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7RE00057J
Citation: React. Chem. Eng., 2017, Advance Article
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    Selective functionalization of complex heterocycles via an automated strong base screening platform

    S. B. Boga, M. Christensen, N. Perrotto, S. W. Krska, S. Dreher, M. T. Tudge, E. R. Ashley, M. Poirier, M. Reibarkh, Y. Liu, E. Streckfuss, L. Campeau, R. T. Ruck, I. W. Davies and P. Vachal, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00057J

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