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Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing

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Abstract

The concept of distributed manufacturing of chemicals is presented and discussed, with specific focus on the context of preparing molecules that can combat the development of geographically-localised resistant strains of infectious pathogens. Specifically we present the case of antimalarial compounds and demonstrate that the flow chemistry community have already designed both a machine capable of distrubuted chemical manufacturing and a module that would be capable of producing artemisin derivatives at the point of use.

Graphical abstract: Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing

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Publication details

The article was received on 06 Mar 2017, accepted on 29 Mar 2017 and first published on 03 Apr 2017


Article type: Minireview
DOI: 10.1039/C7RE00034K
Citation: React. Chem. Eng., 2017, Advance Article
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    Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing

    J. L. Howard, C. Schotten and D. L. Browne, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00034K

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