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Safety assessment in development and operation of modular continuous-flow processes

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Abstract

Improved safety is one of the main drivers for microreactor application in chemical process development and small-scale production. Typical examples of hazardous chemistry are presented indicating potential risks also in miniaturized equipment. Energy balance and kinetic parameters describe the heat production potential and, together with heat transfer capability, the temperature development in a continuous flow reactor. Besides these calculation procedures, checklists for laboratory safety and risk assessment are the basis for improved laboratory work as well as for equipment-related safety discussions. For complete and larger chemical plants, hazard and operation (HAZOP) studies are the appropriate method of handling hazardous processes and their scale-up.

Graphical abstract: Safety assessment in development and operation of modular continuous-flow processes

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Publication details

The article was received on 13 Feb 2017, accepted on 30 Mar 2017 and first published on 30 Mar 2017


Article type: Review Article
DOI: 10.1039/C7RE00021A
Citation: React. Chem. Eng., 2017, Advance Article
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    Safety assessment in development and operation of modular continuous-flow processes

    N. Kockmann, P. Thenée, C. Fleischer-Trebes, G. Laudadio and T. Noël, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00021A

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