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Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

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Abstract

A flow chemistry process for the synthesis of 2-substituted cyclobutanones, via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas, is reported. Our approach uses rapid and mild reaction conditions to access a diverse array of products with good to excellent yield, alongside a good level of functional group compatibility.

Graphical abstract: Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

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Publication details

The article was received on 13 Feb 2017, accepted on 06 Mar 2017, published on 06 Mar 2017 and first published online on 06 Mar 2017


Article type: Communication
DOI: 10.1039/C7RE00020K
Citation: React. Chem. Eng., 2017, Advance Article
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    Flow synthesis of cyclobutanones via [2 + 2] cycloaddition of keteneiminium salts and ethylene gas

    C. Battilocchio, G. Iannucci, S. Wang, E. Godineau, A. Kolleth, A. De Mesmaeker and S. V. Ley, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00020K

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