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Continuous flow dynamic kinetic resolution of rac-1-phenylethanol using a single packed-bed containing immobilized CAL-B lipase and VOSO4 as racemization catalysts

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Abstract

Herein, we report a method for the continuous flow DKR of rac-1-phenylethanol catalyzed by CAL-B and VOSO4, using a single packed-bed containing both catalysts. Taking advantage of continuous flow techniques to circumvent compatibility issues, the DKR of rac-1-phenylethanol could be performed continuously to give enantiopure (R)-esters with excellent conversions and high productivities.

Graphical abstract: Continuous flow dynamic kinetic resolution of rac-1-phenylethanol using a single packed-bed containing immobilized CAL-B lipase and VOSO4 as racemization catalysts

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Publication details

The article was received on 04 Jan 2017, accepted on 15 Feb 2017, published on 15 Feb 2017 and first published online on 15 Feb 2017


Article type: Paper
DOI: 10.1039/C7RE00003K
Citation: React. Chem. Eng., 2017, Advance Article
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    Continuous flow dynamic kinetic resolution of rac-1-phenylethanol using a single packed-bed containing immobilized CAL-B lipase and VOSO4 as racemization catalysts

    A. S. de Miranda, M. V. de M. Silva, F. C. Dias, S. P. de Souza, R. A. C. Leão and R. O. M. A. de Souza, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C7RE00003K

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