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Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

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Abstract

A successful end-to-end continuous flow synthesis of pure curcumin (1) and two other natural derivatives present in turmeric is described. Batch and continuous flow conditions were combined in order to develop the end-to-end process. Three operations were telescoped yielding the three different natural curcuminoids in a safe, gram-scale and reproducible manner.

Graphical abstract: Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

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Publication details

The article was received on 18 Nov 2016, accepted on 15 Feb 2017 and first published on 15 Feb 2017


Article type: Paper
DOI: 10.1039/C6RE00207B
Citation: React. Chem. Eng., 2017, Advance Article
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    Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

    C. C. Carmona-Vargas, L. de C. Alves, T. J. Brocksom and K. T. de Oliveira, React. Chem. Eng., 2017, Advance Article , DOI: 10.1039/C6RE00207B

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