Jump to main content
Jump to site search

Issue 67, 2017, Issue in Progress
Previous Article Next Article

The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex

Author affiliations

Abstract

Curcumin has been known for a long time for its antimicrobial properties that are further increased by exposure to light. Due to the low aqueous solubility of curcumin, appropriate delivery systems are required to facilitate its implementation. In this work, we compared the antimicrobial activity toward Escherichia coli of two curcumin formulations: methyl-β-cyclodextrin supramolecular inclusion complex and polyelectrolyte-coated monolithic nanoparticles. The two formulations showed disparity both in the extent and in the mode of toxicity, highlighting the distinct properties of materials at the nanoscale. The tests showed that while curcumin–β-cyclodextrin complexes exhibited a potent bactericidal activity, the curcumin nanoparticles were bacteriostatic. Illumination with blue light significantly increased the bactericidal efficacy of curcumin–cyclodextrin complexes but had limited influence on the activity of nanoparticulate curcumin. While the antimicrobial effect of the supramolecular complex was predominantly characterized by the increase in ROS and inhibition of electron transport, the primary attributes of the nanoparticle action were membrane depolarization and reduced ATP concentrations. Interestingly, the treatment with curcumin nanoparticles induced a filamentous phenotype of the bacterium. Our results suggest that the antimicrobial properties of curcumin depend upon a delivery formulation, which may have both practical and regulatory implications on the applicability and safety of curcumin nanomaterials.

Graphical abstract: The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Jul 2017, accepted on 29 Aug 2017 and first published on 04 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA07303H
Citation: RSC Adv., 2017,7, 42559-42569
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex

    I. Shlar, S. Droby, R. Choudhary and V. Rodov, RSC Adv., 2017, 7, 42559
    DOI: 10.1039/C7RA07303H

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements