Jump to main content
Jump to site search

Issue 66, 2017, Issue in Progress
Previous Article Next Article

High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring

Author affiliations

Abstract

Rapid and robust hydrogels are essential in realizing continuous glucose monitoring in diabetes monitoring. However, existing hydrogels are limited in satisfying all of the sensory requirements such as detection range, response time, recoverability and biocompatibility. Here, we have developed a surface-initiated polymerization method to chemically immobilize a nano-boronic acid-hydrogel membrane onto a quartz crystal, then used a quartz crystal microbalance (QCM) to achieve real-time monitoring of glucose. The experimental results show that this hydrogel possesses enhanced binding properties to glucose under physiological conditions (pH 7.0–7.5) and blood glucose concentration (BGC) (1.1–33.3 mM). Moreover, our hydrogel displayed a rapid response time (∼100 s) to glucose, high biocompatibility in vivo through an animal model. The hydrogel has a great potential as a sensitive glucose probe for implantable continuous glucose sensors.

Graphical abstract: High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jun 2017, accepted on 17 Aug 2017 and first published on 24 Aug 2017


Article type: Paper
DOI: 10.1039/C7RA06965K
Citation: RSC Adv., 2017,7, 41384-41390
  • Open access: Creative Commons BY license
  •   Request permissions

    High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring

    Q. Dou, D. Hu, H. Gao, Y. Zhang, A. K. Yetisen, H. Butt, J. Wang, G. Nie and Q. Dai, RSC Adv., 2017, 7, 41384
    DOI: 10.1039/C7RA06965K

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements