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Issue 67, 2017, Issue in Progress
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A hydrogen sulfide probe activates Nrf2, inhibits cancer cell growth and induces cell apoptosis

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Abstract

It has been demonstrated that a relatively high level of endogenous hydrogen sulfide (H2S) promotes cancer cell growth. Thus, reducing endogenous H2S levels with a small molecule that selectively targets H2S in cancer cells is an attractive strategy to treat cancer. In this study, we synthesized a 3-hydroxyflavone-based dual probe (HF-NBD) targeting H2S with favourable photostability, and found that it could also activate the nuclear factor erythroid-2-related factor 2 (Nrf2) and upregulate heme oxygenase-1 (HO-1) expression. HF-NBD inhibited the growth of A549 lung cancer cells, U87 malignant glioma cells and HeLa cervical cancer cells, and induced apoptosis in HeLa cells. Herein we provide HF-NBD, a novel Nrf2 activator that promotes HO-1 expression downstream of Nrf2. The data suggested that HF-NBD might be a potential lead compound for the development of new anti-cancer drugs.

Graphical abstract: A hydrogen sulfide probe activates Nrf2, inhibits cancer cell growth and induces cell apoptosis

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Publication details

The article was received on 10 Jun 2017, accepted on 09 Aug 2017 and first published on 01 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA06501A
Citation: RSC Adv., 2017,7, 42416-42421
  • Open access: Creative Commons BY license
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    A hydrogen sulfide probe activates Nrf2, inhibits cancer cell growth and induces cell apoptosis

    Y. Gao, H. Ma, G. Qu, L. Su, Q. Ye, F. Jiang, B. Zhao and J. Miao, RSC Adv., 2017, 7, 42416
    DOI: 10.1039/C7RA06501A

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