Jump to main content
Jump to site search

Issue 52, 2017, Issue in Progress
Previous Article Next Article

Nanoparticles co-delivering pVSVMP and pIL12 for synergistic gene therapy of colon cancer

Author affiliations

Abstract

Nanoparticles delivering therapeutic genes have promising applications in cancer treatments. Here, we used biodegradable heparin–polyethyleneimine (HPEI) nanoparticles to co-deliver two genes (vesicular stomatitis virus matrix protein, VSVMP; interleukin-12, IL12) for cancer therapy. These HPEI nanoparticles can bind the plasmid expressing VSVMP (pVSVMP) and the plasmid expressing IL12 (pIL12) through electrostatic interactions, and mediate the simultaneous expression of VSVMP and IL12 in colon cancer cells in vitro and in vivo. After intraperitoneal administration, the HPEI/pIL12 + pVSVMP complexes efficiently inhibit the growth of intraperitoneal metastasis of C-26 colon cancer, showing synergistic anticancer efficacy, without obvious systemic adverse effects. While VSVMP induces apoptosis, VSVMP and IL12 synergistically generate an anticancer immune response, which renders the potent anticancer effect of HPEI/pIL12 + pVSVMP. Our data suggest that VSVMP and IL12 could synergistically inhibit cancer survival in vivo, and the HPEI nanoparticle co-delivered VSVMP and IL12 might have potential application in treating intraperitoneal metastasis of colon cancer.

Graphical abstract: Nanoparticles co-delivering pVSVMP and pIL12 for synergistic gene therapy of colon cancer

Back to tab navigation

Publication details

The article was received on 31 Mar 2017, accepted on 02 Jun 2017 and first published on 28 Jun 2017


Article type: Paper
DOI: 10.1039/C7RA03727A
Citation: RSC Adv., 2017,7, 32613-32623
  • Open access: Creative Commons BY license
  •   Request permissions

    Nanoparticles co-delivering pVSVMP and pIL12 for synergistic gene therapy of colon cancer

    Y. Xiao, Y. Yang, Y. Wu, C. Wang, H. Cheng, W. Zhao, Y. Li, B. Liu, J. Long, W. Guo, G. Gao and M. Gou, RSC Adv., 2017, 7, 32613
    DOI: 10.1039/C7RA03727A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements