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Issue 19, 2017, Issue in Progress
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Graphene quantum dot-based theranostic agents for active targeting of breast cancer

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Abstract

A novel graphene quantum dot (GQD)-based nanocarrier labeled with Herceptin (HER) and β-cyclodextrin (β-CD) was developed as a promising theranostic candidate for the treatment of breast cancer. Each component of this nanocarrier plays a critical role in providing multiple functions to achieve enhanced anticancer activities. HER provides active targeting to HER2-overexpressed breast cancer to enhance accumulation in the cancer cells. β-CD provides a site for loading of a hydrophobic anticancer drug, doxorubicin (DOX), via “host–guest” chemistry. The nanocarriers also provide diagnostic effects due to the blue-color emission of the GQDs. In response to the acidic environment of cancer cells, the GQD-complex degraded rapidly and the DOX was released in a controlled manner to inhibit proliferation of cancer cells. This multi-functional drug delivery system leads to a synergistically enhanced anticancer strategy which provides treatment and diagnosis. The intracellular trafficking results, along with cell viability and confocal laser scanning microscopy, suggest that the GQD-complex offers a viable strategy for HER2-overexpressed breast cancer-targeting drug delivery applications.

Graphical abstract: Graphene quantum dot-based theranostic agents for active targeting of breast cancer

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Publication details

The article was received on 28 Oct 2016, accepted on 17 Jan 2017 and first published on 14 Feb 2017


Article type: Paper
DOI: 10.1039/C6RA25949A
Citation: RSC Adv., 2017,7, 11420-11427
  • Open access: Creative Commons BY-NC license
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    Graphene quantum dot-based theranostic agents for active targeting of breast cancer

    N. R. Ko, M. Nafiujjaman, J. S. Lee, H.-N. Lim, Y.-k. Lee and I. K. Kwon, RSC Adv., 2017, 7, 11420
    DOI: 10.1039/C6RA25949A

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