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tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction

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Abstract

A tert-butyl peroxybenzoate (TBPB) mediated direct functionalization of N-propargyl aromatic amine derivatives with ethers has been developed. This procedure provides a new strategy toward the synthesis of 3-alkylated quinolines in one step via a domino radical addition/cyclization reaction under metal-free conditions.

Graphical abstract: tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction

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Publication details

The article was received on 24 Nov 2017, accepted on 30 Nov 2017 and first published on 01 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QO01052D
Citation: Org. Chem. Front., 2018, Advance Article
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    tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction

    W. Chen, Y. Zhang, P. Li and L. Wang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO01052D

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