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Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

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Abstract

An efficient one-pot approach to the synthesis of α,α-difluoroketone hydrazones has been developed via visible-light photoredox catalysis. The organic dye acts as an inexpensive and non-toxic photocatalyst, and could be recycled in 95% yield in a large-scale synthesis. This reaction occurs under mild conditions with high step-economy, a broad substrate scope, and excellent functional group compatibility. Moreover, the protocol is applicable to the late-stage functionalization of natural products.

Graphical abstract: Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

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Publication details

The article was received on 15 Oct 2017, accepted on 16 Dec 2017 and first published on 18 Dec 2017


Article type: Research Article
DOI: 10.1039/C7QO00939A
Citation: Org. Chem. Front., 2018, Advance Article
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    Visible-light-promoted organic-dye-catalyzed three-component coupling of aldehydes, hydrazines and bromodifluorinated reagents

    J. Li, L. Li, M. Zhou and H. Wang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00939A

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