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Indium(III)-catalyzed intramolecular dearomative cycloaddition of N-sulfonylaziridines to indoles: facile synthesis of tetracyclic pyrroloindoline skeletons

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Abstract

An indium(III)-catalyzed intramolecular dearomative cycloaddition of N-sulfonylaziridines to indoles has been developed, affording the divergent synthesis of rigid tetracyclic pyrroloindoline skeletons which are present in an array of fascinating natural products with interesting biological activities. In addition, in this reaction system, nonsubstituted indoles at the C3 position could smoothly react with N-sulfonylaziridines to form the desired dearomative cycloadducts for the first time.

Graphical abstract: Indium(iii)-catalyzed intramolecular dearomative cycloaddition of N-sulfonylaziridines to indoles: facile synthesis of tetracyclic pyrroloindoline skeletons

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Publication details

The article was received on 28 Sep 2017, accepted on 16 Oct 2017 and first published on 17 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00882A
Citation: Org. Chem. Front., 2017, Advance Article
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    Indium(III)-catalyzed intramolecular dearomative cycloaddition of N-sulfonylaziridines to indoles: facile synthesis of tetracyclic pyrroloindoline skeletons

    B. Cao, Y. Wei and M. Shi, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00882A

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