Jump to main content
Jump to site search


L-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone

Author affiliations

Abstract

A highly enantioselective formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone was developed. In this transformation, an amino-acid salt L-phenylalanine potassium proved to be a robust organocatalyst, and the corresponding annulation derivatives can be obtained with moderate to excellent yields (up to 99%) and good to excellent enantioselectivities (up to 94%).

Graphical abstract: l-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Sep 2017, accepted on 02 Oct 2017 and first published on 09 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00796E
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    L-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridine N-oxides with acetone

    Y. Xu, S. Zhang, L. Li, Y. Wang, Z. Zha and Z. Wang, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00796E

Search articles by author

Spotlight

Advertisements