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An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems

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Abstract

An efficient, convenient and mild Ru-catalyzed reductive amination reaction was developed by employing H2O as both hydrogen source and solvent via B2(OH)4/H2O systems. The reaction proceeded smoothly under air at ambient temperature and exhibited excellent chemoselectivities toward unsaturated and heteroaromatic as well as aliphatic aldehydes. Interestingly, α-deuterated amines were also obtained expediently by employing D2O in our catalytic systems.

Graphical abstract: An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems

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Publication details

The article was received on 29 Aug 2017, accepted on 27 Sep 2017 and first published on 29 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00769H
Citation: Org. Chem. Front., 2017, Advance Article
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    An expedient and novel strategy for reductive amination by employing H2O as both a hydrogen source and solvent via B2(OH)4/H2O systems

    Y. Wei, C. Zhao, Q. Xuan and Q. Song, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00769H

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