Jump to main content
Jump to site search


Oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles

Author affiliations

Abstract

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed through palladium(0) catalyzed dehydrogenative cyclization of N-arylidenearoylhydrazides. By using this method, a wide range of functionalized and potentially biologically relevant 1,3,4-oxadiazole-containing compounds have been accessed in moderate to high isolated yields. The dehydrogenative cyclization process is characterized by the nonuse of any sacrificing hydrogen acceptors or oxidants and hydrogen gas as the only by-product, and therefore circumvents the recurring problems of over-oxidation and the compatibility with easily oxidizable functionalities in oxidation protocols.

Graphical abstract: Oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Aug 2017, accepted on 11 Oct 2017 and first published on 12 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00749C
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    Oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles

    Q. Jiang, X. Qi, C. Zhang, X. Ji, J. Li and R. Liu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00749C

Search articles by author

Spotlight

Advertisements