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A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

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Abstract

Oxindole/isatin-N-acetamide derivatives are a class of important pharmacologically active compounds. Herein, we report a practical protocol for the synthesis of such derivatives based on palladium-catalyzed intramolecular amination. Various functional groups are tolerated, and the corresponding products are obtained in moderate to good yields, highlighting the potential synthetic utility of this method.

Graphical abstract: A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

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Publication details

The article was received on 11 Aug 2017, accepted on 04 Sep 2017 and first published on 05 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00710H
Citation: Org. Chem. Front., 2017, Advance Article
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    A practical approach for the synthesis of oxindole and isatin derivatives by Pd-catalyzed intramolecular amination

    Y. Pang, M. Guan, R. Zeng and Y. Zhao, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00710H

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