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Iridium catalyzed fragmentation/cyclization of N-butynyl 4,4-dimethylisoxazolidine-3,5-diones: a unique access to multiply substituted pyrroles

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Abstract

A unique protocol for the synthesis of substituted and fused pyrroles has been developed through the iridium catalyzed fragmentation/cyclization of related N-butynyl 4,4-dimethylisoxazolidine-3,5-diones in hot ethanol. Both the substitution pattern and electronic properties can affect the reaction rate and yield.

Graphical abstract: Iridium catalyzed fragmentation/cyclization of N-butynyl 4,4-dimethylisoxazolidine-3,5-diones: a unique access to multiply substituted pyrroles

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Publication details

The article was received on 07 Aug 2017, accepted on 17 Sep 2017 and first published on 18 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00698E
Citation: Org. Chem. Front., 2017, Advance Article
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    Iridium catalyzed fragmentation/cyclization of N-butynyl 4,4-dimethylisoxazolidine-3,5-diones: a unique access to multiply substituted pyrroles

    M. Shen, X. Ren, Y. Pan and H. Xu, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00698E

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